Key findings
Each participant spent a week without TruCBN™, then 21 nights with it, reporting on their sleep every day. Compared with their own baseline week, they slept longer, woke less, felt more refreshed and had better days.
Sleep disturbance fell by a clinically meaningful amount. The average PROMIS Sleep Disturbance T-score dropped 6.8 points, from 60.4 (moderate) to 53.6 (none to slight). A 5-point change is considered meaningful.
More sleep, and more deep sleep. Nightly sleep rose from 5 h 33 m to 6 h 11 m. Among participants who wear a sleep tracker, deep sleep rose from 1 h 42 m to 2 h 13 m.
Far more refreshed mornings. The chance of waking up feeling refreshed rose from 20% to 70%.
Fewer interruptions in the night. The chance of waking during the night fell from 88% to 73%, night wakings fell from 2.8 to 2.2, and falling back asleep got easier.
Better days, too. WHO-5 well-being rose from 44.8 to 54.4, crossing into the good well-being range. Feeling productive rose from 74% to 85% of days, with 32 more productive minutes a day.
Well tolerated. Participants were significantly unlikely to report a hangover or feeling high, and 95% noticed little or no cannabis taste.
Consistent across groups. The improvement in sleep disturbance did not differ significantly by gender, dose, consistency of use or body weight.
How the study worked
This was a real-world study run by MoreBetter for FloraWorks. Participants used TruCBN™ softgels in their everyday lives and answered short surveys every day.
Each participant served as their own comparison. They spent seven nights without TruCBN™, then 21 nights taking it, answering the same daily sleep diary and weekly validated questionnaires throughout. A final survey on day 29 repeated the questions from enrollment.
Analysis. Results were analyzed with mixed-effects models that compare the no-product and product phases while accounting for repeated answers from the same person. Averages on this page are the model estimates, and every change reported here was statistically significant (p < 0.05).
29 days, four phases
Enrollment
Sleep history, satisfaction and demographics
Without TruCBN™
Daily sleep diary and weekly PROMIS and WHO-5
With TruCBN™
The same daily diary and weekly questionnaires, plus product use and effects
Final survey
Enrollment questions repeated, plus overall experience
Participants answering at each check-in
Of 207 adults who enrolled, 20 never used the product and 23 opted out, leaving 164 in the analysis.
Who participated
Participants were mostly women in their 30s to 50s, and for most of them this was their first time trying CBN for sleep.
| Analyzed participants (n = 164) | |||
|---|---|---|---|
| Female / male | 69% / 29% | White | 65% |
| Age 31–40 | 26% | Black or African American | 16% |
| Age 41–50 | 31% | Hispanic | 7% |
| Age 51–60 | 23% | Multiple or other | 7% |
| Age 61 or older | 13% | No cannabis in the 2 weeks before | 57% |
From the study report. In the final survey, 84% of respondents said this was their first time taking a CBN product for sleep.
Sleep disturbance moved from moderate to none-to-slight
Every week, participants completed the PROMIS Sleep Disturbance questionnaire, reported as a T-score where 50 is the general population average and higher means worse sleep. The average fell 6.8 points, more than the 5-point minimally important difference.
Average PROMIS Sleep Disturbance T-score
Model-estimated averages for the no-product and product phases. Band cut-offs: below 55 none to slight, 55–59.9 mild, 60–69.9 moderate, 70 and above severe.
The same benefit across groups. The improvement did not differ significantly by gender, dose, consistency of use or body weight, which suggests TruCBN™ worked similarly across these groups.
Longer, deeper, less interrupted sleep
Every morning, participants answered the same short sleep diary. Comparing their nights with TruCBN™ against their week without it, every sleep measure improved.
Waking up refreshed. The chance that a participant woke feeling refreshed rose from about 1 morning in 5 without TruCBN™ to 7 mornings in 10 with it.
Without vs with TruCBN™
Model-estimated averages. Rating bars are drawn to each scale’s maximum; sleep-time bars are drawn to 8 hours (total sleep) and 3 hours (deep sleep). All differences were statistically significant (p < 0.05).
| Night wakings | Without | With TruCBN™ | Change |
|---|---|---|---|
| Chance of waking during the night | 88% | 73% | −15 pts |
| Times woken per night | 2.8 | 2.2 | −22% |
How participants described their sleep, before and after
At enrollment and again on day 29, participants described their usual sleep. The day 29 answers showed large improvements.
Sleep quality
On a 0–10 scale, up 63%
Hours of sleep a night
About 1 hour 7 minutes more
Times waking at night
42% fewer wakings
Model-estimated averages at enrollment (day 0) and day 29. Satisfaction with falling asleep and with staying asleep also improved significantly, by about 45% each.
Better sleep carried into better days
Participants also rated their well-being, mood and productivity. All of them improved during the weeks with TruCBN™.
WHO-5 Well-Being Index
Scored 0–100. Scores above 50 indicate good well-being. The average rose 9.6 points, crossing the threshold, and the change was both statistically significant and above the minimal important difference.
| Daily diary | Without | With TruCBN™ | Change |
|---|---|---|---|
| Felt productive the day before | 74% | 85% | +11 pts |
| Productive hours the day before | 4 h 37 m | 5 h 10 m | +32 min |
| Morning mood (1 bad to 5 great) | 3.2 | 3.6 | +13% |
| Rating of the overall day (1 to 5) | 3.4 | 3.7 | +9% |
Rarely a hangover, rarely a high
Participants reported side effects and how they felt each morning. Across 21 nights, they were significantly unlikely to report a hangover, feeling high or any negative effect.
What participants said
In the final survey, participants rated statements about their experience and wrote short reviews in their own words.
Final survey responses
TruCBN™ matched or exceeded my expectations
I had more nights of quality sleep
I will recommend TruCBN™ to others
I fell asleep more easily
I fell back asleep more easily after waking
I felt more refreshed in the morning
TruCBN™ improved my overall quality of life
It performed better than any other sleep aid I have tried
Share of the 107 participants who completed the final survey who agreed or strongly agreed with each statement, or who said the product matched or exceeded their expectations.
“This product helped me stay asleep better. When I woke up during the night, I fell right back asleep.”
“No grogginess, felt clear minded. Easy to take and look forward to a better night of rest.”
“I had my doubts but my sleep has been better since taking it. I feel restored when I wake up and my mood and energy is constant throughout the day.”
“The product definitely works for a good night of sleep and has the added benefit of energy the following day. I appreciate not being drowsy or feeling medicated the morning after.”
Better nights and better mornings, in everyday use
In this real-world study of 164 adults, 21 nights of TruCBN™ 50 mg softgels were associated with a clinically meaningful drop in sleep disturbance, longer and deeper sleep, fewer night wakings and far more refreshed mornings than the same participants reported in their week without it.
The benefits carried into the day, with higher well-being, better morning mood and more productive hours. Participants were unlikely to report a hangover or feeling high.
These results add to the evidence from the randomized, placebo-controlled trial of 1,020 adults and the real-world study of 417 adults.
Questions about the study
What did the TruCBN™ MoreBetter 21-night sleep study find?
164 adults compared a week without TruCBN™ with 21 nights taking TruCBN™ 50 mg softgels. Average PROMIS Sleep Disturbance T-scores fell 6.8 points, from 60.4 (moderate) to 53.6 (none to slight). Nightly sleep rose by 38 minutes, deep sleep by 31 minutes among sleep-tracker users, and the chance of waking up refreshed rose from 20% to 70%.
How was the study designed?
It was a real-world study run by MoreBetter for FloraWorks. Each participant served as their own comparison: seven nights without TruCBN™, then 21 nights taking it, with a daily sleep diary, weekly PROMIS Sleep Disturbance and WHO-5 questionnaires, and surveys at enrollment and on day 29. Results were analyzed with mixed-effects models.
How many people took part?
207 adults enrolled. 20 never used the product and 23 opted out, so 164 were analyzed. 69% were female, most were between 31 and 60, and 84% of those who completed the final survey were trying CBN for sleep for the first time.
How much CBN was in each softgel, and how many did people take?
Each TruCBN™ softgel contains 50 mg of cannabinol (CBN). The most common dose participants chose was one softgel, and the most commonly reported time to feel the effects was 20 to 30 minutes.
Did TruCBN™ improve deep sleep?
Among participants who wear a sleep tracker, reported deep sleep rose from 1 hour 42 minutes to 2 hours 13 minutes a night, an increase of 31 minutes.
Did participants feel groggy or high?
Rarely. Participants were significantly unlikely to report a hangover, feeling high or any negative effect, and 95% noticed slight or no cannabis taste.
Did the benefits carry into the next day?
Yes. WHO-5 well-being rose from 44.8 to 54.4, crossing into the good well-being range. Feeling productive rose from 74% to 85% of days, productive hours rose by 32 minutes, and morning mood improved by 13%.
Who ran the study?
The study was conducted by MoreBetter and sponsored by FloraWorks, the maker of TruCBN™. The study report was published in December 2025.
What other research supports TruCBN™?
TruCBN™ was also studied in a randomized, double-blind, placebo-controlled trial of 1,020 adults published in Pharmaceuticals in 2024, and in a separate real-world study of 417 adults taking TruCBN™ 50 mg for 28 days.
References
- MoreBetter. FloraWorks TruCBN™ Softgels Sleep Study. Study report, December 2025.
- Buysse DJ, Yu L, Moul DE, et al. Development and validation of patient-reported outcome measures for sleep disturbance and sleep-related impairments. Sleep. 2010;33(6):781–792.
- Topp CW, Østergaard SD, Søndergaard S, Bech P. The WHO-5 Well-Being Index: a systematic review of the literature. Psychother Psychosom. 2015;84(3):167–176.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Anyone who is pregnant, nursing or taking medication should consult a physician before use.